🌿 Cannabinoids, a lead against fatty liver disease

A team from the Hebrew University of Jerusalem, led by Professor Joseph Tam, has examined the mechanisms of action of two non-psychoactive molecules derived from hemp, CBD and CBG. Their work, published in the British Journal of Pharmacology, specifies that CBD and CBG improve the management of fats and sugars by the liver, thus opening a therapeutic avenue of natural origin.

The first phenomenon observed relates to the energy management of liver cells. The scientists found that CBD and CBG increase the amounts of phosphocreatine, a molecule that acts as a backup energy reserve. This elevation allows the organ to continue its activities despite a diet high in lipids, giving it increased protection against metabolic insults.


Furthermore, these compounds appear to restart internal cellular cleansing mechanisms. Indeed, they reactivate enzymes called cathepsins, located in lysosomes, which break down waste such as fatty deposits. Thanks to this functional restoration, the liver more efficiently evacuates unwanted lipids, which lowers the levels of triglycerides and ceramides involved in inflammatory phenomena.

Despite common effects, CBD and CBG present some distinctions. CBG thus appears more active in improving the response to insulin and decreasing the proportion of body fat. It also more markedly reduces total cholesterol and LDL cholesterol, while both molecules stabilize blood sugar with similar effectiveness.

These observations are encouraging for people presenting with a fatty liver, a condition generally linked to being overweight. The scientific team nevertheless recalls the need for further research in order to confirm these results in humans and to develop appropriate treatments. This phytotherapeutic approach could in the long run expand the available therapeutic arsenal.

Fatty liver: a silent disease

Fatty liver, or hepatic steatosis, corresponds to an accumulation of lipids in the cells of this organ. This condition is often associated with a diet high in sugars and fats, as well as low physical activity. It can remain asymptomatic for many years, making early detection difficult.

In the absence of management, this condition can progress to inflammation, fibrosis, or even cirrhosis. This progression gradually impairs the liver's ability to filter toxins and regulate metabolism, increasing the risks of cardiovascular complications and type 2 diabetes.

The frequency of this pathology is on the rise, affecting nearly one in three adults in some geographical areas. It often appears together with other metabolic disorders such as obesity or hypertension, creating a vicious cycle for general health. Adopting a balanced diet and regular physical activity constitute the primary recommendations.

However, maintaining these good practices over time can prove difficult. This is why the scientific community is actively studying new avenues, including natural substances, to support liver function and limit complications.