Taking this pill produces the same effects as a 10 km run

Could a new compound replace physical exercise? This substitute acts on lactate and ketone levels, two natural substances generated by intense effort.

Developed at Aarhus University, the molecule, called LaKe, simulates the effects of a 10-kilometer (6.2 miles) run on an empty stomach. The results are promising, especially for people unable to follow a strict diet or exercise program.


Ketones and lactate, once viewed as useless by-products, are now recognized as energy fuels. Their release during exercise promotes the reduction of blood fats and decreases the risk of cardiovascular diseases.

The research team successfully fused these two compounds into one, administrable orally. Once ingested, this supplement acts as an exercise simulator, raising lactate and ketone levels in the blood without notable side effects.

Tests on rats showed a reduction in blood fat levels while triggering the production of an appetite-suppressing hormone. These results suggest that this compound could help combat obesity and metabolic syndrome.

The researchers believe that lactate and ketones cannot be ingested in sufficient quantities solely through diet. This is why this new supplement represents a significant breakthrough for individuals with physical limitations.

In addition to metabolic benefits, this compound could also improve recovery for patients suffering from neurodegenerative disorders, such as Parkinson's and Alzheimer's. Studies show that these substances are beneficial for the brain, particularly during periods of stress.

Clinical trials are underway to assess the effectiveness of this supplement in humans. If validated, it could become a pillar in the treatment of various disorders, offering an alternative solution to those unable to engage in regular physical activity.

What are lactate and ketones?

Lactate, often considered a metabolic waste product, is actually a valuable fuel for our cells. It forms when the body breaks down glucose during intense effort. Instead of being eliminated, it is reused by the mitochondria to provide energy, especially during physical exercise.

Ketones, on the other hand, are primarily produced during caloric restriction or prolonged efforts. They allow cells to function, even when glucose is scarce. These molecules are very efficient at powering the mitochondria.

Both of these molecules, lactate and ketones, play a key role in our body's energy regulation. Their levels naturally increase during exercise or fasting. Their ability to substitute for glucose under certain conditions makes them essential, particularly in situations of physiological stress or low caloric intake.