| Compagnies aériennes | Destinations desservies |
|---|
| Aeroméxico | Mexico City |
| AeroRepública | Bogotá, Panama City |
| AeroRepública opéré par Copa Airlines | Guatemala City, Medellín (à partir de juillet 2010). |
| Air Canada | Toronto-Pearson |
| Air Panama | David |
| Air Transat | Montreal-Trudeau, Toronto-Pearson [saisonniers] |
| American Airlines | Dallas/Fort Worth, Miami, New York-JFK |
| Avianca | Bogotá |
| Continental Airlines | Houston-Intercontinental, Newark |
| Condor | Francfort, Santo Domingo |
| Copa Airlines | Guatemala City, Managua, Panama City, San Pedro Sula, Tegucigalpa |
| Cubana de Aviacion | Havana |
| Delta Air Lines | Atlanta |
| Frontier Airlines | Denver [saisonnier] |
| Iberia | Madrid |
| JetBlue Airways | Orlando |
| Mexicana | Cancún, Mexico City |
| Spirit Airlines | Fort Lauderdale |
| TACA | Guatemala City, Mexico City, San Pedro Sula, Tegucigalpa |
| TACA opéré par Sansa Airlines | Barra del Colorado, Bocas del Toro, Coto 47, Drake Bay, Golfito, Liberia (Costa Rica), Limon, Managua, Nosara, Palmar Sur, Puerto Jimenez, Punta Islita, Quepos, Tamarindo, Tambor, Tortuguero. |
| Lacsa | Bogotá, Caracas, David, Guayaquil, Havana, Los Angeles, Managua, Medellín, Miami, New York-JFK, Panama City, Quito, San Salvador, Santo Domingo |
| TACA Peru | Lima |
| US Airways | Charlotte, Philadelphia, Phoenix |
