- Cambarus acanthura
- Cambarus aculabrum (Benton county cave crayfish), EN
- Cambarus acuminatus
- Cambarus angularis
- Cambarus asperigus
- Cambarus asperimanus
- Cambarus bartonii
- Cambarus batchi (Bluegrass Crayfish), VU
- Cambarus bouchardi (Big South Fork Crayfish), VU
- Cambarus brachydactylus
- Cambarus buntingi
- Cambarus carinirostris
- Cambarus carolinus
- Cambarus catagius (Greensboro Burrowing Crayfish), VU
- Cambarus causeyi
- Cambarus chasmodactylus
- Cambarus chaugaensis (Chauga River Crayfish), VU
- Cambarus clivosus
- Cambarus conasaugaensis
- Cambarus coosae
- Cambarus coosawattae (Coosawatee Crayfish), VU
- Cambarus cracens
- Cambarus crinipes
- Cambarus cryptodytes (Dougherty Plain Cave Crayfish), VU
- Cambarus cumberlandensis
- Cambarus cymatilis (Conasauga Blue Burrower), VU
- Cambarus davidi
- Cambarus deweesae(Valley Flame Crayfish), EN
- Cambarus diogenes
- Cambarus distans
- Cambarus doughertyensis
- Cambarus dubius
| - Cambarus elkensis(Elk River Crayfish), VU
- Cambarus englishi
- Cambarus extraneus (Chickamanga Crayfish), VU
- Cambarus fasciatus (Etowah Crayfish), VU
- Cambarus friaufi
- Cambarus gentryi
- Cambarus georgiae (Little Tennessee Crayfish), VU
- Cambarus girardianus
- Cambarus graysoni
- Cambarus halli
- Cambarus hamulatus
- Cambarus harti (Piedmont Blue Burrower), EN
- Cambarus hiwasseensis (Hiwasee Crayfish), VU
- Cambarus hobbsorum
- Cambarus howardi (Chattahoochee Crayfish), VU
- Cambarus hubbsi
- Cambarus hubrichti
- Cambarus hystricosus
- Cambarus jezerinaci
- Cambarus jonesi
- Cambarus laevis
- Cambarus latimanus
- Cambarus lenati
- Cambarus longirostris
- Cambarus longulus
- Cambarus ludovicianus
- Cambarus maculatus
- Cambarus manningi
- Cambarus miltus (Rusty Grave Digger), VU
- Cambarus monongalensis
- Cambarus nerterius (Greenbriar Cave Crayfish), VU
- Cambarus nodosus
| - Cambarus obeyensis (Obey Crayfish), VU
- Cambarus obstipus
- Cambarus ornatus
- Cambarus ortmanni
- Cambarus parrishi (Hiwassee Headwaters Crayfish), VU
- Cambarus parvoculus
- Cambarus pristinus(Pristine Crayfish), VU
- Cambarus pyronotus (Red-black Crayfish), EN
- Cambarus reburrus (French Broad Crayfish), VU
- Cambarus reduncus
- Cambarus reflexus
- Cambarus robustus
- Cambarus rusticiformis
- Cambarus sciotensis
- Cambarus scotti (Chattooga River Crayfish), VU
- Cambarus setosus
- Cambarus speciosus (Beautiful Crayfish), VU
- Cambarus sphenoides
- Cambarus spicatus (Broad River Spiny Crayfish), VU
- Cambarus striatus
- Cambarus strigosus (Lean Crayfish), EN
- Cambarus subterraneus (Delaware County Cave Crayfish), EN
- Cambarus tartarus (Oklahoma Cave Crayfish), CR
- Cambarus tenebrosus
- Cambarus thomai
- Cambarus truncatus (Oconee Burrowing Crayfish), EN
- Cambarus tuckasegee
- Cambarus unestami (Blackbarred Crayfish), VU
- Cambarus veitchorum
- Cambarus veteranus (Big Sandy Crayfish), VU
- Cambarus williami (Brawleys Fork Crayfish), EN
- Cambarus zophonastes (Hell creek cave Crayfish), EN
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